Hydroxy-bisphosphonic acid derivatives as vector for...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/38 (2006.01) A61K 31/663 (2006.01) A61P 3/14 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2711141

The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: - n and m denote, independently of one another, an integer ranging from 1 to 4, - X denotes an oxygen atom or an N-R3 group, - R1 and R3 denote, independently of one another, a linear or branched C1 to C6 alkyl group, and - R2 denotes a residue of a molecule of therapeutic or diagnostic interest, or pharmaceutically acceptable salts of said derivatives, and also the method for the preparation thereof and the therapeutic or diagnostic use thereof.

La présente invention concerne des dérivés d'acide hydroxy-bisphosphonique répondant à la formule générale (I) : dans laquelle :- n et m désignent, indépendamment l'un de l'autre, un nombre entier variant de 1 à 4, - X désigne un atome d'oxygène ou un groupement N-R3, - R1 et R3 désignent, indépendamment l'un de l'autre, un groupement alkyle linéaire ou ramifié en C1 à C6 et - R2 désigne un résidu d'une molécule d'intérêt thérapeutique ou diagnostique, ou des sels pharmaceutiquement acceptables de ceux-ci, ainsi que leur procédé de préparation et leur utilisation thérapeutique ou diagnostique.

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