Hydroxy-methyl isoxazole derivatives as gaba a modulators

Details Hydroxy-methyl isoxazole derivatives as gaba a modulators Hydroxy-methyl isoxazole derivatives as gaba a modulators

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/4439 (2006.01) A61P 25/28 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2749218

The present invention is concerned with novel hydroxy-methyl isoxazole derivatives of formula (I) wherein R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A a5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as medicaments.

Cette invention concerne de nouveaux dérivés d'hydroxyméthylisoxazole de formule (I); R1, R2 et R3 dans la formule I étant tels que décrits dans la présente. Cette invention concerne également des sels et des esters pharmaceutiquement acceptables de ceux-ci. Les principes actifs selon la présente invention ont une certaine affinité et sélectivité pour le récepteur GABA A a5. L'invention concerne, en outre, la fabrication des principes actifs de formule I, des compositions pharmaceutiques les contenant et leur utilisation en tant que médicaments.

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