Hydroxy pipecolate hydroxamic acid derivatives as mmp...

Details Hydroxy pipecolate hydroxamic acid derivatives as mmp... Hydroxy pipecolate hydroxamic acid derivatives as mmp...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/445 (2006.01) A61K 31/4523 (2006.01) C07D 211/96 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2340202

A compound of formula (I) wherein R1, R2 R3, R4 R5, R6, R7, R8, R9 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, and other diseases characterized by matrix metalloproteinase or mammalian reprolysin activity. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S), COX-2 inhibitors and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.

Cette invention se rapporte à un composé représenté par la formule (I) où R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9> et Ar sont définis dans les pièces descriptives de l'invention, ce composé étant utile dans le traitement d'états pathologiques choisis dans le groupe de l'arthrite, du cancer et d'autres maladies se caractérisant par une activité des métalloprotéinases matricielles ou de la reprolysine mammifère. En outre, les composés de cette invention peuvent être utilisés dans des polythérapies en association avec des médicaments anti-inflammatoires non-stéréoïdiens classiques ( NSAID'S), des inhibiteurs de COX-2 et des analgésiques, et en association avec des médicaments cytotoxiques, tels que l'adriamycine, la daunomycine, le cisplatine, l'étoposide, le taxol, le taxotère et d'autres alcaloïdes, tels que la vincristine, dans le traitement du cancer.

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