Hydroxy piperidine derivatives to treat gaucher disease

Details Hydroxy piperidine derivatives to treat gaucher disease Hydroxy piperidine derivatives to treat gaucher disease

C - Chemistry, Metallurgy

07

D

C07D 211/40 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2545435

The present invention provides novel hydroxy piperidine (HP) derivatives having (i) a positive charge at the position corresponding to the anomeric position of a pyranose ring; (ii) a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and (iii) a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof. The linker can be absent if the lipophilic moiety corresponds to a hydrocarbon chain with a linear length of 6 or more carbons. The present invention further provides a method for treating individuals having Gaucher disease by administering the novel HP derivative as "chaperones" for the mutant glucocerebrosidase associated with the disease.

Cette invention se rapporte à de nouveaux dérivés d'hydroxy-pipéridine (HP), comportant: (i) une charge positive dans la position correspondant à la position anomère d'un cycle de pyranose; (ii) un court segment de liaison souple émanant de la position correspondante de l'oxygène cyclique dans une pyranose; et (iii) une fraction lipophile reliée à ce segment de liaison et des sels pharmaceutiquement acceptables de cette fraction. Ce segment de liaison peut être absent si la fraction lipophile correspond à une chaîne d'hydrocarbures ayant une longueur linéaire de 6 carbones au moins. Cette invention concerne en outre un procédé pour traiter des individus souffrant de la maladie de Gaucher en leur administrant ce nouveau dérivé de HP sous la forme de "chaperons" pour la glucocérébrosidase mutante associée à cette maladie.

Affiliated with

Also associated with

Rating

Hydroxy piperidine derivatives to treat gaucher disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydroxy piperidine derivatives to treat gaucher disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxy piperidine derivatives to treat gaucher disease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1915444