C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/32 (2006.01) A61K 31/17 (2006.01) A61P 13/00 (2006.01) A61P 29/00 (2006.01) C07C 275/40 (2006.01) C07C 275/42 (2006.01)
Patent
CA 2487238
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence, inflammatory disorders such as asthma and COPD.
La présente invention concerne des dérivés tétrahydro-naphtalène et certains de leurs sels, convenant comme principe actif de préparations pharmaceutiques. Les dérivés tétrahydro-naphtalène de la présente invention, qui présentent une excellente activité comme antagoniste des VR1, conviennent pour la prophylaxie et le traitement d'affections associées à l'activité des VR1. Les affections concernées sont essentiellement l'incontinence urinaire par impériosité, la vessie hyperactive, la douleur chronique, la douleur neuropathique, la douleur postopératoire, la douleur de la polyarthrite rhumatoïde, la névralgie, les neuropathies, l'algie, le traumatisme nerveux, l'ischémie, la dégénérescence nerveuse, l'ictus cérébral, l'incontinence, et les troubles inflammatoires tels que l'asthme et la broncho-pneumopathie chronique obstructive (BPCO).
Fujishima Hiroshi
Kokubo Toshio
Masuda Tsutomu
Mogi Muneto
Moriwaki Toshiya
Bayer Healthcare Ag
Fetherstonhaugh & Co.
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