C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/478.4, 260/5
C07C 59/66 (2006.01) C07C 45/46 (2006.01) C07C 51/367 (2006.01) C07C 69/76 (2006.01)
Patent
CA 1142542
ABSTRACT OF THE DISCLOSURE The invention concerns novel 2-[4-(4-chlorophenyl)benzyloxy] acetic acids of the formula; Image I in which R1 is hydrogcn or (1-4C)alkyl, R2 is phenyl optionally bearing a halogeno substituent, and R3 is hydrogen or (1-4C)alkyl, and when R3 is hydrogen pharmaceutically acceptable base-addition salts thereof; and processes for their manufacture. The compounds possess useful anti-arthritic properties coupled with desirable pharmacokinetic properties and the minimum of adverse properties, and the invention ?so concerns pharmaceutical com- positions of such compounds for use in the treatment of arthritic joint diseases. A typical compound of the invention is 2-[4-(4-chlorophenyl)ben- zyloxy]-2-phenylpropionic acid.
333277
Imperial Chemical Industries Limited
Smart & Biggar
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