Hydroxyalkanoyl aminolactams and related structures as...

C - Chemistry – Metallurgy – 07 – D

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C07D 243/24 (2006.01) A61K 31/55 (2006.01) A61P 43/00 (2006.01) C07D 223/12 (2006.01) C07D 223/18 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2377221

This invention relates to novel lactams having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome.

L'invention porte sur de nouveaux lactames de formule (I), sur leurs préparations pharmaceutiques, et sur leurs procédés d'utilisation. Ces nouveaux composés inhibent le processus de la protéine précurseur de l'amyloïde et plus spécifiquement la production du peptide A.beta., empêchant par là la formation de dépôts neurologiques de protéines amyloïdes. L'invention porte plus particulièrement le traitement des troubles neurologiques liés à production de l'amyloïde .beta., tels que la maladie d'Alzheimer et le syndrome de Down.

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