Hydroxyalkyl substituted imidazoquinoline compounds and methods

Details Hydroxyalkyl substituted imidazoquinoline compounds and methods Hydroxyalkyl substituted imidazoquinoline compounds and methods

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4162 (2006.01)

Patent

CA 2598656

Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, and an aryl or heteroaryl substituent at the 7-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-.alpha. biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

L'invention concerne certaines imidazoquinolines présentant un substituant hydroxyméthyle ou hydroxyéthyle à la position 2, et un substituant aryle ou hétéroaryle à la position 7, des compositions pharmaceutiques contenant lesdits composés, des intermédiaires, des procédés de préparation et des procédés d'utilisation desdits composés en tant qu'immunomodulateurs, afin d'induire préférentiellement une biosynthèse d'IFN-a chez des animaux, ainsi que dans le traitement de maladies, notamment des maladies virales et néoplasiques.

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