Hydroxyalkyl substituted imidazoquinolines

Details Hydroxyalkyl substituted imidazoquinolines Hydroxyalkyl substituted imidazoquinolines

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2598695

Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-.alpha. biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

La présente invention concerne certains imidazoquinolines portant un substituant hydroxyméthyle ou hydroxyéthyle en position 2, des compositions pharmaceutiques contenant ces composés, des intermédiaires, des procédés de fabrication et d'utilisation de ces composés en tant qu'immunomodulateurs, de préférence pour induire une biosynthèse d'IFN-a chez des animaux, et pour le traitement d'affections, y-compris virales et néoplasiques.

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