Hydroxyalkyl substituted xanthine derivatives

Details Hydroxyalkyl substituted xanthine derivatives Hydroxyalkyl substituted xanthine derivatives

C - Chemistry, Metallurgy

07

D

260/242.4

C07D 473/04 (2006.01) C07D 473/06 (2006.01) C07D 473/08 (2006.01) C07D 473/10 (2006.01)

Patent

CA 1062709

Abstract of the Disclosure Xanthine compounds, and processes for their preparation of formula Image wherein: R1 represents (a) an .omega.-hydroxyalkyl radical of 4 to 8 carbon atoms or (b) an (.omega.-1)-hydroxyalkyl radical having 4, 5, 7, or 8 carbon atoms; or (c) a 5-hydroxyhexyl group, or (d) an alkyl radical of 1 to 12 carbon atoms, or (e) hydrogen; R2 represents an .omega.- or (.omega.-1) hydroxyalkyl radical of 4 to 8 carbon atoms, or an alkyl radical of 1 to 12 carbon atoms; R3 represents (a) an .omega.-hydroxyalkyl radical of 6 to 8 carbon atoms, or (b) an (.omega.-1) hydroxyalkyl radical of 4 to 8 carbon atoms or (c) an alkyl radical having 4 to 8 carbon atoms, or (d) hydrogen, provided that: (i) at least one of the groups R1, R2, or R3 represents a hydroxyalkyl group as defined above in respect of R1, R2 and R3; (ii) R1 only represents a 5- hydroxyhexyl group if at least one of R2 and R3 is an alkyl radical other than methyl, or if R3 is hydrogen; and (iii) at least one of the groups R1, R2 and R3 contains at least 5 carbon atoms, and in which definitions .omega.- and (.omega.-1) mean the terminal carbon atom of the group distant from the xanthine ring system, and the carbon atom adjacent to the terminal one, respectively. These compounds find use in medicaments to improve blood circulation.

178591

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