C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/205 (2006.01) A61K 31/18 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07C 311/10 (2006.01) C07D 295/215 (2006.01)
Patent
CA 2526989
The invention relates to novel compounds for the inhibition of the urokinase plasminogen activator (uPA) with high bioavailability and which can also be administered orally, and to the use thereof as therapeutic active ingredients for the treatment of urokinase or/and urokinase receptor associated diseases, such as, for example, tumours and metastization. The invention especially relates to compounds (I) and (II) that contain hydroxyamidine or hydroxyguanidine groups, wherein E represents a group consisting of (a).
L'invention concerne de nouveaux composés servant à inhiber l'activateur du plasminogène de type urokinase (uPA). Ces nouveaux composés présentent une biodisponibilité élevée et sont destinés à être administrés oralement. La présente invention se rapporte en outre à l'utilisation desdits composés en tant que substances à action thérapeutique pour traiter des maladies associées à l'urokinase et/ou au récepteur de l'urokinase, par exemple des tumeurs ou des métastatisations. Cette invention concerne notamment des composés comportant des groupes hydroxyamidine ou hydroxyguanidine.
Buergle Markus
Clement Bernd
Schmalix Wolfgang
Sperl Stefan
Wosikowski Katja
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Wilex Ag
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