C - Chemistry – Metallurgy – 08 – J
Patent
C - Chemistry, Metallurgy
08
J
C08J 5/12 (2006.01) A61F 2/28 (2006.01)
Patent
CA 2528092
A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
La présente invention concerne une composition qui comprend (i) un macromère préparé par réaction d'un diacide insaturé comprenant une double liaison carbone-carbone avec un diacide saturé, et (ii) une céramique bioactive greffée sur le macromère. Dans un mode de réalisation, le diacide insaturé comprenant une double liaison carbone-carbone, est de l'acide fumarique, le diacide saturé est compatible avec l'acide fumarique et le poly(propylène fumarate) tel que l'acide succinique, l'acide glutarique, l'acide adipique, l'acide pimélique, l'acide subérique, l'acide azélaïque, l'acide sébacique et des mélanges de ceux-ci, et la céramique bioactive est l'hydroxyapatite. Dans un autre mode de réalisation, l'hydroxyapatite est greffée sur un macromère réticulable et biodégradable comprenant des unités silane alternées avec des unités fumarate et adipate.
Currier Bradford L.
Jabbari Esmaiel
Lu Lichun
Yaszemski Michael J.
Bcf Llp
Mayo Foundation For Medical Education And Research
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