Hydroxyapatite-targeting multiarm polymers and conjugates...

Details Hydroxyapatite-targeting multiarm polymers and conjugates... Hydroxyapatite-targeting multiarm polymers and conjugates...

C - Chemistry, Metallurgy

08

G

C08G 65/335 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2702945

The present invention provides, among other things, polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains and a plurality of hydroxyapatite-targeting moieties, and optionally the reagents include one or more degradable linkages that serve to divide the polymer chains into polymer segments having a molecular weight suitable for renal clearance.

La présente invention concerne, entre autres, des réactifs polymères appropriés pour une réaction avec des agents biologiquement actifs pour former des conjugués. Selon l'invention, les réactifs polymères comprennent une ou plusieurs chaînes polymères et une pluralité de fonctions ciblant l'hydroxyapatite, et les réactifs comprennent éventuellement une ou plusieurs liaisons dégradables qui servent à diviser les chaînes polymères en segments polymères ayant un poids moléculaire approprié pour la clairance rénale.

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