Hydroxyazido derivatives and related compounds as renin...

Details Hydroxyazido derivatives and related compounds as renin... Hydroxyazido derivatives and related compounds as renin...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07K 5/023 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2110381

2110381 9221696 PCTABS00017 Novel compounds useful as renin inhibitors are provided. The compounds are hydroxyazido derivatives having structural formula (1), wherein the substituents R1 through R7 are as defined herein. Analogs of these compounds which are ketoazido derivatives are also provided. Additionally disclosed are methods for using the novel compounds to treat hypertension, and pharmaceutical compositions containing the compounds. Of particular interest are formulations for oral administration.

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