Hydroxybutyrate and poly-hydroxybutyrate as components of...

A - Human Necessities – 23 – K

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Details

A23K 1/16 (2006.01) A23L 1/30 (2006.01) A61K 31/045 (2006.01) A61K 31/185 (2006.01) A61K 35/74 (2006.01) A61P 1/12 (2006.01)

Patent

CA 2650716

This invention relates to the use of hydroxybutyrate and poly hydroxybutyrate as components of animal feed or feed additives, as well as to compositions, feed additives and feed containing them. The inventors surprisingly found that hydroxybutyrate and poly- hydroxybutyrate, preferably 3 -hydroxybutyrate and poly-3 -hydroxybutyrate, have a great potential for use in animal feed for modulation of the gut flora. More precisely, it has been found that poly-3 -hydroxybutyrate or a microbial strain capable for producing poly-3- hydroxybutyrate can be used as a potential growth promoter or gut flora modulator by releasing SCFA, preferably 3 -hydroxy butyric acid, in the gut micro flora. Further, the inventors found that 3 -hydroxybutyrate and poly-3 -hydroxybutyrate have a great potential for suppressing or inhibiting pathogenic bacteria in the gastro intestinal tract, e.g. have a antimicrobial activity against strains of Vibrio, E.coli and Salmonella.

L'invention concerne l'utilisation de l'hydroxybutyrate et du polyhydroxybutyrate en tant que composants d'aliments pour animaux ou d'additifs aux aliments pour animaux, ainsi que les compositions, additifs aux aliments pour animaux et aliments pour animaux qui les contiennent. Les inventeurs ou découvert avec surprise que l'hydroxybutyrate et le polyhydroxybutyrate, de préférence le 3-hydroxybutyrate et le poly-3-hydroxybutyrate, ont un énorme potentiel quand utilisés dans les aliments pour animaux à des fins de modulation de la flore intestinale. Plus précisément, il a été découvert que le poly-3-hydroxybutyrate, ou une souche microbienne capable de produire le poly-3-hydroxybutyrate, peut être utilisé à titre de promoteur de croissance ou de modulateur de flore intestinale en libérant des SCFA (acides gras à chaîne courte), de préférence l'acide 3-hydroxy butyrique, dans la micro-flore intestinale. De plus, les inventeurs ont découvert que le 3-hydroxybutyrate et le poly-3-hydroxybutyrate ont un grand potentiel pour la suppression ou l'inhibition de bactéries pathogènes dans le tractus gastro-intestinal, par exemple, qu'elles exercent une activité antimicrobienne à l'endroit des souches de Vibrio, d'E.coli et de Salmonella.

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