C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/675 (2006.01) A23L 1/30 (2006.01) A61K 31/22 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2734720
A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3.LAMBDA.) hydroxybutyl (3i?)-hydroxybutyrate of formula (I): is an effective and palatable precursor to the ketone body (3.LAMBDA.)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of, neuro degeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.
La présente invention concerne un composé qui est le 3-hydroxybutyl 3-hydroxybutyrate énantiomériquement enrichi par comparaison au (3?)-hydroxybutyl (3i?)-hydroxybutyrate de formule (I) : Ce composé est un précurseur, efficace et agréable au goût, du corps de cétone (3?)-hydroxybutyrate et peut donc être utilisé pour traiter un état qui est causé par, exacerbé par ou associé à des niveaux élevés d'acides gras libres dans le plasma chez un sujet humain ou animal, par exemple un état dans lequel la perte de poids ou le gain de poids est impliqué, ou pour favoriser la vigilance ou améliorer la fonction cognitive, ou pour traiter, prévenir ou réduire les effets de la neurodégénérescence, de la toxicité des radicaux libres, des états hypoxiques ou de l'hyperglycémie.
Clarke Kieran
Veech Richard Lewis
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Department Of He Alth And Human Services Government Of The Usa As Represented By The Secretary
Isis Innovation Limited
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