C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4985 (2006.01) A61K 31/522 (2006.01) A61K 31/7072 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2634499
Bi-or tricyclic compounds of formula (I) wherein R1, R4 and R5 are as herein defined, A represents a single or double bond and two R2, R2', R3 and R3' can be joined to form a condensed or spiro ring. These compounds and their pharmaceutical acceptable salt are used in combinations or pharmaceutical compositions and are useful in methods for preventing or treatin human immunodeficiency virus (HIV) infection or in methods for preventing, delaying or treating acquired immunodeficiency syndrome (AIDS).
Composés bi- ou tricycliques de formule (I) dans lesquels R<SUB>1</SUB>, R<SUB>4</SUB> et R<SUB>5</SUB> sont tels que définis ici, A représente une liaison simple ou double et deux R<SUB>2</SUB>, R<SUB>2</SUB>', R<SUB>3</SUB> et R<SUB>3</SUB>' peuvent être groupés pour former un cycle condensé ou spiro. Ces composés et leurs sels pharmaceutiquement acceptables sont utilisés dans des combinaisons ou des compositions pharmaceutiques et sont utiles dans des procédés pour prévenir ou traiter l'infection par le virus de l'immunodéficience humaine (VIH) ou dans des procédés pour prévenir, retarder ou traiter le syndrome d'immunodéficience acquise (SIDA).
Cadilhac Caroline
Chan Chun Kong Laval
Liu Bingcan
Nguyen-Ba Nghe
Turcotte Nathalie
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Virochem Pharma Inc.
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