C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/26 (2006.01) A61K 31/4015 (2006.01) A61K 31/425 (2006.01) A61K 31/45 (2006.01) A61K 31/541 (2006.01) A61P 25/28 (2006.01) C07D 207/267 (2006.01) C07D 211/76 (2006.01) C07D 275/02 (2006.01) C07D 279/02 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2508325
The present invention relates to novel hydroxyethylamine compounds of formula (I): (I) having Asp2 (-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated - amyloid levels or -amyloid deposits, particularly Alzheimer's disease.
L'invention concerne de nouveaux composés d'hydroxyéthylamine de formule (I), présentant une activité inhibitrice de l'Asp2 (.beta.-sécrétase, BACE1 ou mémapsine), des procédés pour leur préparation, des compositions les contenant, ainsi que leur utilisation dans le traitement de maladies caractérisées par des taux de substances amyloïdes élevés ou des dépôts amyloïdes importants, en particulier la maladie d'Alzheimer.?¿
Demont Emmanuel H.
Faller Andrew
Macpherson David Timothy
Milner Peter Henry
Naylor Alan
Glaxo Group Limited
Gowling Lafleur Henderson Llp
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