Hydroxyflavone derivatives as tau protein kinase 1 inhibitors

Details Hydroxyflavone derivatives as tau protein kinase 1 inhibitors Hydroxyflavone derivatives as tau protein kinase 1 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 311/30 (2006.01) A61K 31/35 (2006.01) A61K 31/352 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2345311

A medicament for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity or a neurodegenerative disease which comprises as an active ingredient a substance selected from the group consisting of a hydroxyflavone derivative represented by formula (I) and a salt thereof, and a solvate thereof and a hydrate thereof, wherein R1 represents hydrogen atom or hydroxyl group; R2 represents hydrogen atom or a C1-C18 alkyl group which may have one or more C6-C14 aryl groups; and Ar represents a C6-C14 aryl group which may be substituted or an aromatic heterocyclic group which may be substituted.

Cette invention concerne un médicament permettant de prévenir et/ou de traiter une maladie induite par une hyperactivité de la tau-protéine-kinase 1, ou une maladie neuro-dégénéréscente. Ce médicament comprend en qualité d'ingrédient actif une substance choisie dans le groupe représenté par un dérivé d'hydroxyflavone correspondant à la formule générale (I) où R?1¿ représente un atome d'hydrogène ou un groupe hydroxyle, R?2¿ représente un atome d'hydrogène ou un groupe alkyle C¿1?-C¿18? pouvant comporter un ou plusieurs groupes aryle C¿6?-C¿14?, tandis que Ar représente un groupe aryle C¿6?-C¿14? pouvant être substitué ou un groupe hétérocyclique aromatique pouvant être substitué. Cette invention concerne également un sel, un solvat et un hydrate de ce dérivé.

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