C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/278, 260/291
C07D 211/90 (2006.01) C07D 209/48 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 1221966
Abstract: Hydroxyimino and alkoxyimino derivatives of 1,4- dihydropyridine, process for the preparation there- of and pharmaceutical compositions therefrom Compounds of formula I: Image (I) are described in which R1 is a linear or branched alkyl radical containing between 1 and 5 carbon atoms, the alkyl radical being unsubstituted or sub stituted by an alkoxy group; R2 is an unsubstituted phenyl of phenyl substituted by a nitro group; R3 is hydrogen or a linear or branched alkyl residue containing between 1 and 4 carbon atoms, the alkyl radical being unsubstituted or substituted by at least one alkoxy or fluorine atom or both alkoxy and fluorine atoms; R4 is hydrogen or a linear or branched alkyl containing between 1 and 4 carbon atoms, the alkyl radical being unsubstituted or sub stituted by alkoxy, carbalkoxy, dialkylamino, 1- aryl or 1-heteroarylpiperazinyl, aryl or a monocy- clic 5 or 6 membered heterocycle in which at least one of the heteroatoms is N,O,S such as 1-piperi- dinyl, 4-morpholinyl or R4 is alkenyl or cyclo(C3- C6)alkyl; and enantiomers, racemates, diastereoiso mers and isomers (E) and (Z) and their salts with pharmaceutically acceptable acids. The novel compounds exhibit calcium-antagonistic activity.
429372
Casagrande Cesare
de Marchi Franco
Nicola Massimo
Tricerri Silvia Z.
Kirby Eades Gale Baker
Pierrel S.p.a.
LandOfFree
Hydroxyimino and alkoxyimino derivatives of 1,4-... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hydroxyimino and alkoxyimino derivatives of 1,4-..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxyimino and alkoxyimino derivatives of 1,4-... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1227947