Hydroxyl-containing compounds

Details Hydroxyl-containing compounds Hydroxyl-containing compounds

C - Chemistry, Metallurgy

07

D

C07D 473/06 (2006.01) A61K 31/16 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/519 (2006.01) C07C 233/91 (2006.01) C07C 317/18 (2006.01) C07D 209/48 (2006.01) C07D 211/76 (2006.01) C07D 211/88 (2006.01) C07D 215/22 (2006.01) C07D 239/54 (2006.01) C07D 239/88 (2006.01) C07D 239/96 (2006.01) C07D 295/088 (2006.01) C07D 473/08 (2006.01) C07D 473/10 (2006.01) C07D 475/02 (2006.01)

Patent

CA 2151617

Disclosed are therapeutic compounds having the formula: (R)j - (core moiety), including resolved enantiomers, diastere- omers, hydrates, salts, solvates and mixtures thereof. j is an integer from one to three, the core moiety is either non-cyclic or com- prises at least one five- to seven-membered ring structure, R may be selected from the group consisting of hydrogen, halogen, hy- droxyl, amino, substituted or unsubstituted benzyl, C1-6 alkyl or C1-6 alkenyl, and at least one R has formula (I), wherein n is an integer from seven to twenty and at least one of X or Y is -OH. The other of X or Y, which is not -OH, is hydrogen, CH3-, CH3-CH2-, CH3-(CH2)2- or (CH3)2-CH2-, and each W1, W2, and W3 is independently hydrogen, CH3-, CH3-CH2-, CH3-(CH2)2- or (CH3)2-CH2-. The X, Y, W1, W2, or W3 alkyl groups may be unsubstituted or substituted by an hydroxyl, halo or dimethylamino group. The disclosed compounds and therapeutic compositions thereof are useful in treating individ- uals having a disease or treatment-induced toxicity, mediated by second messenger activity.

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