Hydroxylamine compounds

Details Hydroxylamine compounds Hydroxylamine compounds

C - Chemistry, Metallurgy

07

C

260/296, 260/591

C07C 239/20 (2006.01) C07C 251/58 (2006.01) C07D 213/42 (2006.01)

Patent

CA 2040103

4-18032/A Hvdroxylamine compounds Abstract Compounds of formula Image (I), wherein R1 is amino or is a radical Image wherein R3 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, carboxy, lower alkoxycarbonyl, phenyl, phenyl substituted by lower alkyl, halo-lower alkyl, hydroxy- lower alkyl, halogen, hydroxy, lower alkoxy, lower alkanoyloxy and/or by nitro, pyridyl, pyridyl substituted by lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, phosphonooxy-lower alkyl, lower alkanoyl, carboxy, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkanoyloxy, nitro and/or by oxido, or quinolyl, R4 is hydrogen, lower alkyl, hydroxy-lower alkyl or halo-lower alkyl, or R3 and R4 together are C4-C6alkylene or benzo-C4-C6alkylene, and R2 is straight-chain C1-C4alkyl, and salts thereof, have a strong specific inhibitory action on the enzyme ornithine decarboxylase. The compounds of formula I are prepared according to processes known per se.

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