Hydroxylamine compounds and methods of their use

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 207/46 (2006.01) A61K 31/4535 (2006.01) A61P 17/18 (2006.01) C07D 209/44 (2006.01) C07D 211/94 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2679066

The present disclosure provides compounds that include hydroxylamines of formula (I) or (II), pharmaceutical compositions, and methods for their use. The methods utilize hydroxylamine compounds and/or their pharmaceutical compositions for the treatment of angiogenesis, hepatitis, complement-mediated pathologies, drusen-mediated pathologies, macular degeneration and certain other ophthalmic conditions, inflammation, arthritis, and related diseases and for the inhibition of complement activation.

La présente invention concerne des composés qui comprennent des hydroxylamines de formule I ou II, des compositions pharmaceutiques et leurs procédés d'utilisation. Les procédés utilisent des composés d'hydroxylamine et/ou leurs compositions pharmaceutiques pour le traitement de l'angiogenèse, de l'hépatite, de pathologies médiées par le complément, de pathologies médiées par des druses, d'une dégénérescence maculaire et de certaines autres affections ophtalmiques, d'une inflammation, d'une arthrite et de maladies associées et pour l'inhibition de l'activation du complément.

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