Hydroxylamine derivatives

Details Hydroxylamine derivatives Hydroxylamine derivatives

C - Chemistry, Metallurgy

07

C

C07C 239/12 (2006.01) A61K 31/13 (2006.01) A61P 25/00 (2006.01) C07C 239/20 (2006.01)

Patent

CA 2548572

This invention is related to hydroxylamino derivatives of the general formula (I) wherein n is 0, l or 2; R1 and R2, independently of each other, are H, OH or OCH3; R3 is H or CH3; R4 is H, C1-C3 straight or branched alkyl or, together with R3, forms a five to seven-membered carbocyclic ring; and R5 and R6, independently of each other, are H or C1-C5 straight or branched alkyl and the pharmaceutically acceptable salts or prodrug thereof, for the preparation of medicaments useful for the prevention, treatment and diagnosis of CNS degenerative disorders related to protein misfolding and/or misaggregation. The invention also relates to novel compounds included in formula (I), to a method for preparing said compounds and to pharmaceutical compositions containing them.

L'invention concerne des dérivés hydroxylamino de la formule générale (1) dans laquelle n est 0, 1 ou 2; R?1¿ et R?2¿, indépendamment l'un de l'autre, sont H, OH ou OCH¿3?; R?3¿ est H ou CH¿3?; R?4¿ est H, un alkyle linéaire ou ramifié en C¿1?-C¿3? ou, avec R?3¿, forme un noyau carbocyclique de cinq à sept chaînons; et R?5¿ et R?6¿, indépendamment l'un de l'autre, sont H ou un alkyle linéaire ou ramifié en C¿1?-C¿5,? et les sels pharmaceutiquement acceptables ou les promédicaments de ces derniers, utilisés dans la préparation de médicaments destinés à prévenir, traiter et diagnostiquer les troubles dégénératifs du système nerveux central liés au mauvais repliement et/ou à la mauvaise agrégation des protéines. L'invention porte également sur de nouveaux composés inclus dans la formule (1), sur un procédé de préparation desdits composés et sur des compositions pharmaceutiques les contenant.

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