Hydroxylamine substituted imidazo-containing compounds

Details Hydroxylamine substituted imidazo-containing compounds Hydroxylamine substituted imidazo-containing compounds

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 31/4745 (2006.01) A61P 31/12 (2006.01) A61P 37/02 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2535120

Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, imidazopyridines) with a hydroxylamine substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

L'invention concerne des composés contenant une structure imidazo (imidazoquinolines, imidazonaphthyridines et imidazopyridines, par exemple) avec un substituant hydroxylamine en position 1, des compositions pharmaceutiques contenant ces composés, des produits intermédiaires et des méthodes d'utilisation de ces composés comme immunomodulateurs, pour induire la biosynthèse de cytokines chez des animaux et pour traiter des maladies, y compris des maladies virales et cancéreuses.

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