Hydroxylamine substituted imidazo ring compounds

Details Hydroxylamine substituted imidazo ring compounds Hydroxylamine substituted imidazo ring compounds

C - Chemistry, Metallurgy

07

D

C07D 471/00 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2545825

Imidazo ring compounds (e.g., imidazoquinolines, 6, 7, 8, 9- tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

L'invention concerne des composés d'un anneau d'imidazo (par exemples, imidazoquinolines, 6, 7, 8, 9-tétrahydroimidazoquinolines, imidazonaphthyridines, et imidazopyridines) avec un substituant d'hydroxylamine au niveau de la position 2, des compositions pharmaceutiques contenant ces composés, et des intermédiaires. Cette invention a aussi trait à des méthodes d'utilisation de ces composés en tant qu'immunomodulateurs destinés à induire une biosynthèse de la cytokine chez des animaux et dans le traitement de maladies, y compris, virales et néoplasiques.

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