Hydroxylated metabolites and derivatives of doxazosin as...

Details Hydroxylated metabolites and derivatives of doxazosin as... Hydroxylated metabolites and derivatives of doxazosin as...

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2092983

This invention relates to the use of certain hydroxylated metabolites and derivatives of doxazosin of the formula: Image I and their pharmaceutically acceptable acid addition salts for retarding the development of atherosclerosis in a mammal. Such compounds are useful for reducing atherosclerotic plaque involvement and for retarding and reducing both lipid deposition fibrosis in the development of atherosclerotic plaques.

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