Hydroxymethyl-indolizidines and quinolizidines

Details Hydroxymethyl-indolizidines and quinolizidines Hydroxymethyl-indolizidines and quinolizidines

C - Chemistry, Metallurgy

07

D

167/231, 260/271

C07D 455/02 (2006.01) A61K 31/44 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2038984

The present invention describes a group of polyhydroxylated indolizidines and quinolizidines and their esters. These compounds have the general formula: Image They are prepared starting from 2,6-dideoxy-2,6-imino-1,3,4,5- tetrakis-O-(phenylmethyl)-D-glycero-L-gulo-heptitol or a corresponding N-substituted compound. The compounds are useful in the treatment of diabetes and as a-glucosidase I inhibitors.

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