Hydroxymethyl-pyridine esters and a process for the...

Details Hydroxymethyl-pyridine esters and a process for the... Hydroxymethyl-pyridine esters and a process for the...

C - Chemistry, Metallurgy

07

D

260/296, 260/297

C07D 405/12 (2006.01) C07D 213/30 (2006.01) C07D 213/55 (2006.01)

Patent

CA 1099271

A B S T R A C T New hydroxymethyl-pyridine esters of the general formula Image (I) wherein R represents a 9-xanthenyl group or a phenyl group substituted by a halogen atom or a trifluoromethyl group or by an alkyl or alkoxy group both having 1 to 4 carbon atoms, and pharmaceutically acceptable acid addition salts and quaternary salts thereof are prepared by acylating the corresponding hydroxymethyl pyridines with a carboxylic acid of the general formula R-COOH, wherein R has the same meaning as above, or with a reactive derivative thereof, and, if desired, converting the obtained product of the general formula I into a pharmaceutically acceptable acid addition salt or quaternary salt thereof. The new compounds exert beneficial effects on functional disorders of the heart.

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