Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for...

Details Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for... Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4523 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) C07D 295/155 (2006.01) C07D 307/52 (2006.01) C07D 333/20 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2402705

Compounds of general formula (I), where R1 is selected from any one of pyridinyl, thienyl, furanyl, imidazolyl, and triazolyl; where each R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as separate enantiomers of the compounds and salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

L'invention concerne des composés représentés par la formule générale (I). Dans cette formule, R?1¿ est sélectionné dans l'un quelconque des groupes pyridinyle, thiényle, furanyle, imidazolyle, et triazolyle, chaque noyau hétéroaromatique R?1¿ pouvant éventuellement et indépendamment être substitués par 1, 2 ou 3 substituants sélectionnés dans alkyle C¿1?-C¿6? linéaire ou ramifié, NO¿2?, CF¿3?, alcoxy C¿1?-C¿6?, chloro, fluoro, bromo, et iodo. Les substitutions effectuées sur le noyau hétéroaromatique peuvent s'effectuer au niveau de n'importe quelle position des systèmes de noyau. L'invention concerne également la séparation d'énantiomères des composés, sels et compositions pharmaceutiques comprenant ces nouveaux composés, ainsi que leur utilisation en thérapie, notamment dans la gestion de la douleur.

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