Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide...

Details Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide... Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4523 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) C07D 211/68 (2006.01) C07D 211/70 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2404386

Compounds of general formula (I) where R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, triazolyl and thiazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

Cette invention concerne des composés représentés par la formule générale (I) dans laquelle R?1¿ peut être indifféremment phényle, pyridinyle, thiényle, furanyle, imidazolyle, triazolyle et thiazolyle; dans laquelle chaque chaque noyau de phényle R?1¿et chaque anneau hétéroaromatique R?1¿ peut éventuellement et indépendamment être également substitué par 1, 2 ou 3 substituants pris dans C¿1?-C¿6? alkyle droit ou ramifié, NO¿2?, CF¿3?, C¿1?-C¿6? alkoxy, chloro, fluoro, bromo, et iodo. Les substitutions sur le noyau phényle et sur le noyau hétéroaromatique peuvent se produire en n'importe quel point desdits systèmes de noyaux. L'invention concerne également des sels et des compositions pharmaceutiques renfermant les nouveaux composés ainsi que leur utilisation thérapeutique, en particulier comme analgésiques.

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