C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/08 (2006.01) A61K 31/165 (2006.01) A61P 25/28 (2006.01) C07C 233/18 (2006.01) C07C 255/26 (2006.01) C07C 271/22 (2006.01) C07D 303/36 (2006.01)
Patent
CA 2543756
The present invention relates to compounds of formula (I) useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-~secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
L'invention concerne des composés de formule générale (I), utiles pour le traitement de la maladie d'Alzheimer et d'autres maladies identiques. Ces composés comprennent des inhibiteurs de l'enzyme .beta.-sécrétase qui sont utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par le dépôt du peptide .beta.-amyloïde chez un mammifère. Les composés de l'invention sont utiles dans des compositions pharmaceutiques et dans des méthodes de traitement permettant de réduire la formation de peptides .beta.-amyloïde.
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company Llc
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