Hydroxypropylamines

Details Hydroxypropylamines Hydroxypropylamines

C - Chemistry, Metallurgy

07

C

C07C 215/28 (2006.01) A61K 31/135 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C07C 233/78 (2006.01) C07C 311/17 (2006.01) C07D 263/04 (2006.01) C07D 263/32 (2006.01)

Patent

CA 2462851

Disclosed are compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein the variables R~N, R~1, R~2, R~3, R~p and R~c are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta- secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

L'invention concerne des composés de formule (I) et leurs sels pharmaceutiquement acceptables dans lesquels les variables Rn, R1, R2, R3, Rp et Rc ont la signification indiquée dans la description. Ces composés sont utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies semblables. Lesdits composés comprennent des inhibiteurs de l'enzyme bêta-secrétase qui sont utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par le dépôt du peptide A bêta chez un mammifère. Les composés de l'invention sont utiles dans des compositions pharmaceutiques et des méthodes de traitement destinées à réduire la formation du peptide A bêta.

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