Hydroxystyrene derivative

Details Hydroxystyrene derivative Hydroxystyrene derivative

C - Chemistry, Metallurgy

07

D

167/179, 260/302

C07D 209/34 (2006.01) C07D 277/36 (2006.01) C07D 279/16 (2006.01)

Patent

CA 1315783

Abstract of the Disclosure A hydroxystyrene derivative represented by the formula (I): Image (I) wherein when R1 and R2 are the same or different and each is phenyl group, benzyl group or phenethyl group, or R1 is a group having the formula: R5O- in which R5 is hydrogen atom, an alkyl group having 1 to 5 carbon atoms or benzyl group and R2 is benzyl group or group having the formula: PhSCH2, R3 and R4 are taken together to represent a group having the formula: -CONH-CS-S-, a group having the formula: -CONH Image , a group having the formula: -CONH Image SO2- or a group having the formula: Image in which R6 is a group having the formula: Image [in which X1 is hydrogen atom, a halogen atom, methyl group, ethyl group, an alkoxyl group having the formula: R7O- (in which R7 is methyl or ethyl group), nitro group, aminosulfonyl group or amino group, and m1 is 1 or 2], pyridyl group, furyl group or thienyl group, and n1 is 0 or an integer of 1 to 3; when R1 and R2 are the same or different and each is phenyl group, benzyl group or phenethyl group, or R1 is a group having the formula: R5O- in which R5 is as defined above, and R2 is benzyl group, R3 is cyano group and R4 is a carbamoyl group, or R3 and R4 are taken together to represent a group having the formula: -CO-Y-CH2CH2- in which Y is oxygen atom or -NH-, or a group having the formula: -CO-?-NH-CO-; and when R1 and R2 are the same or different and each is an alkyl group having 1 to 3 carbon atoms, R3 and R4 are taken together to represent a group having the formula: Image in which n1 and R6 are as defined above, or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

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