Hydroxythienoquinolones and related compounds as...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 495/04 (2006.01) A61P 29/00 (2006.01) C07D 495/14 (2006.01) C07D 495/16 (2006.01)

Patent

CA 2756701

Disclosed herein are hydroxythienoquinolones and related compounds and their pharmaceutically acceptable salts useful as antiviral agents and having the general formula (I) in which the variables R2, R6, and R7 are defined herein. Certain com-pounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity and are particularly efficacious for the treatment of MRSA infections. The invention also provides pharmaceutical compositions, pharmaceutical compositions contain-ing a hydroxythienoquinolone in combination with one or more other active agent, and methods of treating microbial infections in animals by administering an effective amount of a hydroxythienoquinolone or related compound to an animal suffering from a mi-crobial infection.

La présente invention concerne des hydroxylthiénoquinolones, des composés apparentés et leurs sels pharmaceutiquement acceptables, utilisables en tant qu'agents antiviraux et de formule générale (I), dans laquelle les variables R2, R6 et R7 sont telles que définies ici. Certains des composés de l'invention présentent une intense activité antibactérienne, antiprotozoaire ou antifongique et se révèlent particulièrement efficaces dans le cadre du traitement des infections à staphylocoques dorés résistant à la méthicilline. L'invention concerne également des compositions pharmaceutiques, des compositions pharmaceutiques contenant une hydroxylthiénoquinolone en association avec un ou plusieurs autres agents actifs, ainsi que des méthodes de traitement d'infections microbiennes chez les animaux grâce à l'administration d'une quantité efficace d'une hydroxylthiénoquinolone ou d'un composé apparenté à un animal souffrant d'une telle infection microbienne.

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