Hygromycin a derivatives

Details Hygromycin a derivatives Hygromycin a derivatives

C - Chemistry, Metallurgy

07

H

C07H 15/203 (2006.01) A61K 31/70 (2006.01) C12P 19/44 (2006.01)

Patent

CA 2331297

The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1 and R2 are as defined herein. The compounds of formula (1) are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula (1) and the methods of treating bacterial and protozoal infections by administering the compounds of formula (1).

L'invention concerne des composés représentés par la formule (<u>1</u>), ainsi que leurs sels, promédicaments et solvates acceptables sur le plan pharmaceutique, dans laquelle R<1> et R<2> sont tels qu'ils sont définis dans le descriptif. Ces composés sont des agents antibactériens et antiprotozoaires qu'on peut mettre en application afin de traiter différentes infections bactériennes et protozoaires et des troubles apparentés à ces infections. Elle concerne également des compositions pharmaceutiques contenant ces composés et des procédés servant à traiter des infections bactériennes et protozoaires par administration de ces composés.

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