Hyperbaric pressurization of proteins and therapeutical uses...

A - Human Necessities – 23 – L

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Details

A23L 1/305 (2006.01) A23J 3/00 (2006.01) A23L 1/025 (2006.01) A23L 3/015 (2006.01)

Patent

CA 2396103

The present invention relates to hyperbaric pressurization of proteins and therapeutical uses of such pressurized proteins as stimulatory growth and/or antioxidant and/or tissue glutathione inducing agents. There is provided a protein composition having enhanced susceptibility to enzymes for administration to an animal, which comprises between 1% (w/w) to 100% (w/w) protein prepared by the method of the present invention; and an acceptable pharmaceutical carrier between 0% (w/w) to 99% (w/w). The present invention also relates to induce conformational changes in proteins to reduce their allergenic properties by exposing proteins to a hyperbaric treatment. There is provided a protein composition having reduced allergenic effects for administration to an animal, which comprises between 1% (w/w) to 100% (w/w) protein prepared by the method of the present invention; and an acceptable pharmaceutical carrier between 0% (w/w) to 99% (w/w).

L'invention concerne la pressurisation hyperbare de protéines et des utilisations thérapeutiques de ces protéines pressurisées comme agents de stimulation de croissance et/ou antioxydants et/ou glutathions de tissus. Il est prévu une composition de protéine ayant une susceptibilité accrue aux enzymes pour l'administration à un animal, comprenant entre 1 % (m/m) et 100 % (m/m) d'une protéine préparée suivant le procédé de l'invention ; et un support pharmaceutiquement acceptable compris entre 0 % (m/m) et 99 % (m/m). L'invention concerne également des moyens permettant de provoquer des changements conformationnels dans des protéines en vue de réduire leurs propriétés allergènes, en soumettant ces protéines à un traitement hyperbare. L'invention permet d'obtenir une composition de protéine ayant des effets allergènes réduits pour l'administration à un animal, renfermant entre 1 % (m/m) et 100 % (m/m) d'une protéine préparée conformément au procédé de l'invention ; et un support pharmaceutiquement acceptable compris entre 0 % (m/m) et 99 % (m/m).

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