Hyperbranched polyglycerol for improving heart function

Details Hyperbranched polyglycerol for improving heart function Hyperbranched polyglycerol for improving heart function

A - Human Necessities

61

K

A61K 31/765 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2742345

A method of improving heart function in a subject, the method comprising administering an effective amount of a hyperbranched polyglycerol to a subject. The improvement in heart function may include one or more of an increase in myocardial contractile function, reduced or absent fibrosis, an increase in mechanical efficiency of the heart, an increase in ejection fraction, an increase in glucose oxidation or a decrease in fatty acid oxidation, as determined by conventional methods known in the art.

L'invention porte sur un procédé d'amélioration de la fonction cardiaque chez un sujet. Ce procédé comprend l'administration d'une quantité efficace d'un polyglycérol hyperramifié à un sujet. L'amélioration de la fonction cardiaque peut comprendre un ou plusieurs parmi une augmentation de la fonction contractile du myocarde, une fibrose réduite ou absente, une augmentation du rendement mécanique du cur, une augmentation de la fraction d'éjection, une augmentation de l'oxydation du glucose ou une diminution de l'oxydation des acides gras, comme déterminé par des procédés classiques connus dans la technique.

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