Hyperhydrated citicoline, process and use

Details Hyperhydrated citicoline, process and use Hyperhydrated citicoline, process and use

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2316989

A hyperhydrated form of citicoline and its formulations, which exhibits desirable characteristics, including crystal formation, moisture resistance, improved storage stability, and formulation versatility, is disclosed. Methods of preparing the citicoline hyperhydrate and its use in the manufacture of stable pharmaceutical dosage forms are also described.

La présente invention concerne un forme hyperhydratée de citicoline et ses formulations. Ladite forme présente des caractéristiques souhaitées, dont la cristallisation, la résistance à l'humidité, une meilleure stabilité de stockage et une grande diversité de formulation. Des procédés de préparation de ladite citicoline hyperhydratée et son utilisation dans la préparation de formes posologiques pharmaceutiques stables sont également décrits.

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