Hypertension associated transcription factor-1 (hatf-1) and...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/20 (2006.01) C12N 15/00 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2341149

The invention provides isolated nucleic acids molecules, designated HATF-1 and HRP-1 nucleic acid molecules, which are differentially expressed in hypertensive humans, rats, and mice. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HATF-1 or HRP-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an HATF-1 or HRP-1 gene has been introduced or disrupted. The invention still further provides isolated HATF-1 and HRP-1 proteins, fusion proteins, antigenic peptides and anti-HATF-1 and anti-HRP-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

L'invention concerne des molécules d'acide nucléique isolées, appelées HATF-1 et HRP-1, qui sont exprimées de manière différentielle chez les humains, les rats et les souris souffrant d'hypertension. Elle se rapporte encore à des molécules d'acide nucléique, à des vecteurs d'expression recombinés contenant les molécules d'acide nucléique HATF-1 ou HRP-1, à des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits, et à des animaux transgéniques non-humains dans lesquels le gène de HATF-1 ou HRP-1 a été introduit ou interrompu. Elle porte encore sur des protéines de HATF-1 et HRP-1, des protéines de fusion, des peptides antigéniques et des anticorps anti-HATF-1 et anti-HRP-1. Des méthodes de diagnostic dans lesquelles les compositions de l'invention sont utilisées sont également décrites.

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