Hypertension markers

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 9/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2267637

The present invention relates to a method of detecting for an individual mammal a high likelihood of having hypertension or a genetic predisposition for having hypertension, the method comprising determining the presence in a biological sample from the individual mammal of at least one marker protein which is indicative of a high likelihood of having hypertension or a genetic predisposition for having hypertension, wherein the marker protein is selected from the group consisting of the proteins shown in Table 1. In a further aspect the invention relates to novel proteins, nucleic acid fragments and use of said proteins or nucleic acid fragments for detection of whether an individual mammal has a high likelihood of having hypertension or a genetic predisposition for having hypertension as well as test kits for this purpose.

L'invention concerne une méthode de détection chez un mammifère, un risque élevé d'hypertension ou une prédisposition génétique à l'hypertension. Ladite méthode consiste à déterminer la présence dans un échantillon biologique prélevé sur ledit mammifère d'au moins une protéine marqueuse signalant un risque élevé d'hypertension ou une prédisposition génétique à l'hypertension, ladite protéine étant choisie dans le groupe constitué des protéines répertoriées dans le tableau 1. L'invention se rapporte aussi à des nouvelles protéines, des fragments d'acide nucléique et leur utilisation pour la détection du risque élevé d'hypertension chez un mammifère ou de la prédisposition génétique à l'hypertension ainsi que sur des trousses d'essai prévues à cet effet.

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