C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2308575
Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods therefor. Inducible expression of the transgenes at high levels under physiologic conditions results from induction by hyperthermic conditions relative to the basal temperature of the host cells.
L'invention concerne des procédés et des compositions utiles pour exprimer des transgènes dans des cellules cibles. L'invention concerne des produits de recombinaison d'expression utilisant un système d'amplification inductible pour diriger l'expression d'un gène thérapeutique ou d'un autre gène intéressant dans des cellules hôtes de mammifère, ainsi que des procédés utiles à cet effet. L'expression inductible des transgènes à des concentrations élevées dans des conditions physiologiques est la conséquence d'une induction provoquée par des conditions d'hyperthermie par rapport à la température de base des cellules hôtes.
Gerner Eugene
Harris David T.
Hersh Evan
Tsang Tom
Dennison Associates
The Arizona Board Of Regents On Behalf Of The University Of Ariz
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