Hypertonic isochloremic formulation for circulatory shock

Details Hypertonic isochloremic formulation for circulatory shock Hypertonic isochloremic formulation for circulatory shock

A - Human Necessities

61

K

A61K 33/14 (2006.01) A61K 33/00 (2006.01) A61K 33/26 (2006.01) A61K 33/30 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2103246

2103246 9221356 PCTABS00017 The present invention relates to a hypertonic crystalloid resuscitation fluid particularly useful in treating circulatory shock arising from loss of blood. A pharmaceutical formulation prepared from sodium chloride in a range of about 2-7 osmolar parts and sodium acetate in a range of about 1-2 osmolar parts where the total osmolar concentration exceeds 500 mOsm can be used as a small volume rapid bolus resuscitation fluid which has little effect on plasmachloride levels. Blood flow is improved while arterial pressure is improved to the point of sustaining oxygen supply to tissues and organs in the recumbent recipient.

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