Hyperuretic agents

A - Human Necessities – 61 – K

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A61K 31/495 (2006.01) A61K 31/54 (2006.01) C07D 241/24 (2006.01) C07D 241/26 (2006.01)

Patent

CA 1183456

TITLE OF THE INVENTION HYPERURETIC AGENTS ABSTRACT OF THE DISCLOSURE Hyperuretic agents of the formula: Image wherein Y is O or NH; R1is OH;2NHCONR4R5; or N=C(NR4R5)2; R1 and R2 are amino, or mono- or disubstituted - 2 - amino, provided that R1 and R2 may not both be amino or substituted amino; and R is hydrogen or halo; enhance renal excretion of urea, thereby lowering plasma urea concentration, and are therefore useful for treating hypertension, eclampsia, uremia, and similar disorders; and may be used in combination with saluretic agents such as hydrochlorothiazide for treating hypertension.

418427

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