C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 9/00 (2006.01) A61K 38/43 (2006.01) A61K 38/46 (2006.01) A61K 39/35 (2006.01) A61P 37/08 (2006.01) C07K 14/435 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) A61K 9/19 (2006.01)
Patent
CA 2513836
The present invention provides a treatment for allergy comprising the provision of a recombinant Der p 1/ProDer p 1/PreProDer p 1 allergen derivative, ProDer p 3 or a recombinant ProDer p 3/Der p 3/ PreProDer p 3 allergen derivative with hypoallergenic activity. Pharmaceutical compositions comprising said mutant allergens which stimulate a Th1-type immune response in allergic or naïve individuals thereby reducing the potential for an allergic response upon contact with the wild-type allergen, are also provided.
L'invention concerne un nouveau traitement des allergies qui consiste à utiliser un dérivé d'allergène Der p 1/ProDer p 1/PreProDer p 1 de recombinaison, ProDer p 3 ou ProDer p 3/Der p 3/ PreProDer p 3 de recombinaison à activité hypoallergénique. L'invention concerne également des compositions pharmaceutiques comprenant lesdits allergènes mutants qui stimulent une réaction immunitaire de type Th1 chez des sujets allergiques ou novices, ce qui permet de réduire le potentiel d'une réaction allergique après un contact avec l'allergène de type sauvage.
Glaxosmithkline Biologicals S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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