Hypocholesterolemically active protein

Details Hypocholesterolemically active protein Hypocholesterolemically active protein

C - Chemistry, Metallurgy

12

P

530/15.04, 195/1

C12P 21/00 (2006.01) C07K 14/315 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1225957

- 25 - HYPOCHOLESTEROLEMICALLY ACTIVE PROTEIN ABSTRACT OF THE DISCLOSURE A hypocholesterolemically active protein capable of reducing the blood cholesterol in mammals having the following characteristics: (a) Molecular weight by gel filtration: 30,000 ? 7,000 (b) Isoelectric point: 7.9 ? 0.2 (c) Amino acid composition (mole %): Glycine 25.23 Alanine 10.98 Glutamate 10.34 Asparaginate 8.20 Lysine 6.39 Leucine 5.58 Valine 5.41 Isoleucine 5.18 Threonine 4.23 Tyrosine 4.19 Serine 3.46 Proline 2.62 Arginine 2.60 Phenylalanine 2.51 Methionine 1.56 Histidine 1.30 Cysteine 0.16 (d) Pattern of electrophoresis: a sharp band on the anode side on polyacrylamide gel electro- phoresis. This hypocholesterolemically active protein is derived from a microorganism belonging to the genus Streptococcus.

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