Hypocholesterolemically active rna fractions

Details Hypocholesterolemically active rna fractions Hypocholesterolemically active rna fractions

A - Human Necessities

61

K

195/1.23

A61K 31/70 (2006.01) A61K 35/74 (2006.01) C12P 19/34 (2006.01)

Patent

CA 1276897

HYPOCHOLESTEROLEMICALLY ACTIVE RNA FRACTIONS ABSTRACT OF THE DISCLOSURE Hypocholesterolemically active RNA fractions having the following characteristics: (a) Molecular weight by gel filtration: 11,000?9,000 (b) Base composition ratio of nucleic acid: uracil:guanine:cytosine:adenine=1:1:2:1 (c) Infrared absorption spectrum: shown in Figure 2 (d) Physiological characteristics: having a hypocholesterolemic activity in mammals. These hypocholesterolemically active RNA fractions can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypocholesterolemically active RNA fractions from the cultured cells of the microorganism. These hypocholesterolemically active RNA fractions can be used as an active ingredient of a hypocholesterolemic or antiatherosclerotic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypocholesterolemic or antiatherosclerotic pharmaceutical composition, which is suitable for oral administration to mammals.

498599

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