C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/1.28
C12P 19/34 (2006.01) A61K 31/70 (2006.01) C07H 21/02 (2006.01)
Patent
CA 1276898
HYPOCHOLESTEROLEMICALLY AND/OR HYPOTRIGLYCERIDEMICALLY ACTIVE RNA FRACTIONS ABSTRACT OF THE DISCLOSURE Hypocholesterolemically and/or hypotriglyceridemi- cally active RNA fractions having the following characteristics: (a) Molecular weight by gel filtration: 2,000 ? 1,000 (b) Base composition ratio of nucleic acid: uracil : guanine : cytosine : adenine = 13.0 : 16.0 : 16.0 : 10.0 (c) Infrared absorption spectrum: shown in Figure 2 (d) Physiological characteristics: having a hypocholesterolemic and/or hypotriglyceridemic activity in mammals. These hypocholesterolemically and/or hypotriglycer- idemically active RNA fractions can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypocholesterolemically and/or hypotriglyceridemically active RNA fractions from the cultured cells of the microorganism. These hypocholes- terolemically and/or hypotriglyceridemically active RNA fractions can be used as an active ingredient of a hypocholesterolemic or hypotriglyceridemic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypocholesterolemic or hypotriglyceridemic pharmaceutical composition, which is suitable for oral administration to mammals.
512300
Kawai Yasuo
Yazawa Kazunaga
Kabushiki Kaisya Advance Kaihatsu Kenkyujo
Kawai Yasuo
Malcolm Johnston & Associates
Yazawa Kazunaga
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