C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/04 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 5/50 (2006.01) C07K 5/02 (2006.01) C07K 5/103 (2006.01) C07K 5/113 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2452069
A peptide of the formula (Xaa)n1-Xaa1-His-Thr-Asp-(Xaa)n2, wherein Xaa is any amino acid; Xaa1 is a hydrophobic amino acid, preferably Gly or Val; n1 is 0- 10; and n2 is 0-10; and use thereof in regulating in vivo blood glucose levels in a human or other mammal, particularly in the treatment of Type 2 diabetes in a human. Preferably, the peptide is a tetrapeptide selected from Gly-His- Thr-Asp and Val-His-Thr-Asp. These hypoglycaemic peptides are isolated from human urine and they also have been chemically synthesized.
La présente invention concerne un peptide de formule (Xaa)¿n1?-Xaa¿1?-His-Thr-Asp-(Xaa)¿n2?, où Xaa est n'importe quel acide aminé; Xaa¿1? est un acide aminé hydrophobe, de préférence un Gly ou Val; n1 est 0-10; et n2 est 0-10; et son utilisation dans la régulation in vivo des taux de glycémie chez un humain ou chez un autre mammifère, notamment dans le traitement du diabète de type 2 chez un humain. De préférence, ledit peptide est un tétrapeptide sélectionné dans Gly-His-Thr-Asp et Val-His-Thr-Asp. Lesdits peptides hypoglycémiques peuvent être isolés dans de l'urine humaine et ils peuvent également être synthétisés chimiquement.
Ng Frank Man-Woon
Zimmet Paul Zev
Dia-B Tech Limited
International Diabetes Institute
Monash University
Sim & Mcburney
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