Hypoglycemic thiazolidinediones and intermediates

Details Hypoglycemic thiazolidinediones and intermediates Hypoglycemic thiazolidinediones and intermediates

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01) A61K 31/425 (2006.01) C07D 417/10 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2111447

Optically pure thiazolidinedione alcohols and ethers of the formula: Image (wherein Y is CH~OH, CH~OH or CH~OR in which R is alkyl, phenylalkyl, phenyl or alkoxyalkyl) and synthetic intermediates for preparing the alcohols and ethers. These compounds have utility as hypoglycemic and hypocholesterolemic agents. Process for the preparation of a series of optically pure thiazolidinedione alcohols and ethers. Pharmaceutical compositions of the alcohols ethers including pharmaceutically acceptable acid addition salts thereof.

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